Myo-inositol is the supplemental name of Inositol.

Inositol, found in your body, in some foods, and as a supplement, plays a crucial role in the development and growth of cells. Research indicates that inositol may offer numerous potential health benefits, and people utilize it for various health conditions, including metabolic syndrome and polycystic ovary syndrome (PCOS).

What Is Inositol

Inositol is a naturally occurring form of sugar produced by your body to support the structure of cells. It is also present in various foods such as meat, fruits, corn, beans, grains, and legumes. While the average American diet includes about 1 gram of inositol daily, research suggests that supplementing with inositol may offer numerous health benefits.

Although often referred to as vitamin B8, inositol is not technically a vitamin. Nevertheless, research indicates that it serves several essential functions. Apart from its role in cell membrane development, inositol may impact insulin and certain neurotransmitters in the brain. This influence could potentially affect your body’s ability to manage conditions related to both metabolic and mental health.

Supplements of Inositol

As a supplement, inositol is commonly known by three main forms:

• Myo-inositol: This is the most common and naturally occurring form of inositol. It is often used in supplements and has been studied for its potential benefits in various health conditions, including polycystic ovary syndrome (PCOS) and anxiety.

• D-chiro-inositol: Another stereoisomer of inositol, D-chiro-inositol, is also used in supplements. It is particularly studied for its potential role in insulin sensitivity and PCOS management.

• Inositol hexaphosphate: Also known as phytic acid, this form of inositol is found in certain high-fiber foods like whole grains and legumes. It is not typically used as a standalone supplement, but it may contribute to the overall inositol intake in the diet.

These different forms of inositol may have distinct roles and effects in the body, and individuals may choose a specific form of inositol based on their health goals and conditions.

Benefits of Inositol

Inositol is essential for the functioning and development of your cells. While ongoing research explores its various health benefits, people actively use inositol for reasons such as:

• Lowering the risk of metabolic syndrome.
• Alleviating symptoms associated with polycystic ovary syndrome (PCOS).
• Reducing the risk of gestational diabetes and preterm birth.
• Lowering elevated cholesterol levels.
• Improving the body’s insulin processing.
• Potentially alleviating symptoms related to depression and other mood disorders.

Uses of Myo-inositol

Inositol supplements like myo-inositol are widely utilized for various health conditions, and research has indicated its potential benefits in the following areas:

Metabolic Syndrome

Inositol supplementation may assist in managing risk factors associated with metabolic syndrome, such as excess abdominal fat, high triglyceride levels, low HDL cholesterol levels, high blood pressure, and elevated blood sugar. Preliminary studies suggest potential improvements in blood pressure, triglycerides, cholesterol, and blood sugar levels.

Polycystic Ovary Syndrome (PCOS)

For individuals with PCOS, inositol supplementation, particularly when combined with folic acid, may alleviate symptoms like irregular periods, infertility, acne, weight gain, and excess hair growth. Research indicates potential improvements in blood sugar, blood pressure, and triglyceride levels, as well as increased ovulation and pregnancy rates.

Related: Effect of Exercise on PCOS

Gestational Diabetes (GD) and Preterm Birth

In pregnant individuals, taking an inositol supplement with folic acid may help prevent gestational diabetes and reduce the risk of preterm birth. Gestational diabetes poses complications during pregnancy and elevates the risk of preterm delivery.

Depression

Some studies suggest that individuals with depression may have low levels of inositol in their brains. Inositol supplementation might help balance key hormones in the brain, including serotonin and dopamine, potentially improving depressive symptoms. However, more research is needed.

Panic Disorder

Limited research suggests that inositol supplementation may reduce the frequency and severity of panic attacks in individuals with panic disorder. It is essential to consult with healthcare providers and not discontinue prescribed medications.

Bipolar Disorder

Adding an inositol supplement to prescribed treatments may potentially reduce symptoms of bipolar disorder, as suggested by limited studies. Consulting with healthcare providers before starting such a supplement is crucial.

In addition to these conditions, inositol is used for various other health issues, although scientific evidence supporting its efficacy is less substantial. These conditions include insomnia, post-traumatic stress disorder (PTSD), acute respiratory distress syndrome (ARDS), type 2 diabetes, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). It is important to note that further research is needed to establish the effectiveness of inositol for these purposes, and individuals should consult with healthcare providers before initiating supplementation.

Safety

Healthcare providers typically deem inositol safe when taken in low doses for up to 10 weeks. However, it is crucial not to discontinue medications prescribed by your provider without consulting them first. In many instances, inositol supplements may be incorporated into treatment plans, but they are not meant to replace prescribed medications.

While taking the inositol supplement, you may encounter some mild side effects, such as:

• Diarrhea
• Nausea
• Abdominal pain
• Fatigue
• Headache
• Dizziness

If you experience any of these side effects or have concerns about your treatment plan, it is essential to communicate with your healthcare provider for guidance and adjustments.

Summary

Inositol, crucial for the growth and development of your cells, is a form of sugar your body requires. However, research indicates that supplementing with inositol may offer numerous additional health benefits. In the treatment of various metabolic and mental health conditions, inositol shows promise, although further research is necessary. When taken at low doses, the supplement appears to be safe, causing only very mild side effects. It is important to always consult with your healthcare provider about the use of any vitamins and supplements.

References

1. Croze, M. L., & Soulage, C. O. (2013). Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 95(10), 1811–1827. doi:10.1016/j.biochi.2013.05.011
2. professional, C. C. medical. (n.d.). Retrieved from https://my.clevelandclinic.org/health/drugs/25173-inositol